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Personalized hormone therapy

In stockCompounded estradiol hormone therapy, offered as a cream, an oral capsule, and a transdermal patchCompounded female testosterone cream from Sipra
Lab fees included
CompoundedHormone therapy
From$89/mo

+ Sipra membership*

Get Started

* Medication only. A $99/mo Sipra membership is billed separately.
Cream, oral or patch from $89/mo, in 1, 3 or 6 month plans. Prices may vary.

Compounded in the USAFSA and HSA eligiblePay over time withKlarnaAfterpayAffirm
  • Personalized hormone therapy
  • Clinician-reviewed and monitored
  • 24/7 support
  • No hidden fees, no surprise charges

Hormone therapy can ease the symptoms of perimenopause and menopause, hot flashes, sleep, mood, brain fog, vaginal comfort, and low libido, by replacing the hormones your body makes less of. A licensed clinician reviews your history and labs, prescribes the right hormones and format (cream, oral, or patch), and stays with you through follow-up. Female testosterone is offered separately, off-label, for low desire and energy.

Hormone therapy replaces the estrogen and progesterone your body makes less of in perimenopause and menopause, easing symptoms like hot flashes, sleep changes, mood, and vaginal discomfort. It comes as a cream, an oral capsule, or a patch. Female testosterone is a separate, off-label option for low sexual desire and low energy; there is no FDA-approved testosterone product for women. Your clinician helps you decide what fits your symptoms and history, and you can be on one or both.

Compounded medications are not FDA-approved. Individual results vary.

Every Sipra plan is built around you. After a licensed clinician reviews your health profile and labs, you receive a personalized treatment plan. If hormone therapy is right for you, we craft your prescription and ship it to your door through a certified, state-licensed pharmacy. You will also get unlimited 24/7 messaging with your dedicated care team, so you are supported every step of the way.

The membership is what turns a prescription into ongoing care. It covers your licensed clinician, lab fees, your follow-up visit, unlimited 24/7 messaging with your care team, and the dose adjustments and monitoring that keep treatment working and safe over time. One membership covers unlimited visits across every treatment you are on, so if you add another medication later, you save instead of paying a second set of fees. We keep it separate from the medication on purpose, so your care is funded transparently and you never pay a hidden markup buried in the price of your medication.

You can cancel your treatment plan anytime from your online patient portal. There are no cancellation fees. Note that canceling in the portal does not cancel any active orders already sent to the pharmacy. If your order is pending, contact us at [email protected] and we will help.

The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve any compounded medications for safety or effectiveness.

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Explore women's treatments

Hormone therapy and targeted add-ons, prescribed and monitored by licensed clinicians.

HRT Cream (Estradiol/BIEST + Testosterone ± Progesterone)
HRT Cream (Estradiol/BIEST + Testosterone ± Progesterone)Topical estradiol for menopause symptomsFrom $89/mo
HRT
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HRT Oral (Estradiol tablet + Oral Micronized Progesterone)
HRT Oral (Estradiol tablet + Oral Micronized Progesterone)Daily oral estradiol for hormone balanceFrom $149/mo
HRT
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HRT Patch (Brand Dotti estradiol patch + Oral Progesterone)
HRT Patch (Brand Dotti estradiol patch + Oral Progesterone)Transdermal estradiol, changed twice weeklyFrom $279/mo
HRT
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Female Testosterone (standalone — libido/energy)
Female Testosterone (standalone — libido/energy)Low-dose testosterone for energy and libidoFrom $79/mo
HRT
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Progesterone (sleep/mood) capsule
Progesterone (sleep/mood) capsuleBalances estrogen, supports sleepFrom $49/mo
Hormone support
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PT-141 (Bremelanotide) libido
PT-141 (Bremelanotide) libidoBoosts desire and arousalFrom $99/mo
Sexual wellness
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Vaginal Estradiol cream (GSM / dryness)
Vaginal Estradiol cream (GSM / dryness)Local estrogen for drynessFrom $49/mo
Vaginal health
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Scream Cream (topical arousal)
Scream Cream (topical arousal)Topical blend for arousalFrom $49/mo
Sexual wellness
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Female hair (Minoxidil/Spironolactone combo cap)
Female hair (Minoxidil/Spironolactone combo cap)Minoxidil + spironolactone for regrowthFrom $49/mo
Hair
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ReGrow Fuel
ReGrow FuelStimulates follicles for thicker hair
Hair
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Lush Lox
Lush LoxMinoxidil + biotin for regrowth
Hair
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DHEA vaginal / cream (GSM / libido)
DHEA vaginal / cream (GSM / libido)Vaginal DHEA for comfortFrom $29/mo
Vaginal health
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Thyroid T3/T4 (compounded) capsule
Thyroid T3/T4 (compounded) capsuleSupports energy and metabolismFrom $59/mo
Thyroid
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Tadalafil/Oxytocin troche (12-count)
Tadalafil/Oxytocin troche (12-count)Eases arousal and closenessFrom $49/mo
Sexual wellness
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DHEA (energy) capsule
DHEA (energy) capsuleDHEA for libido and energyFrom $25/mo
Sexual wellness
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Menopause symptoms

Every symptom, mapped to care

Every stage of menopause hits differently. Click a symptom to discover your personalized treatment:

Get startedCheck eligibility

Prevalence data from NAMS and published clinical literature. Treatment options are illustrative, your physician will recommend a personalized plan. Individual results vary.

Estrogen levels across the menopause transition

Estrogen levelsreplenish with HRT
Estrogen levels dropwithout HRT

Illustrative. Individual results vary.

Personalized medicine,
in four simple steps

Get startedCheck eligibility
Submit your application
and check eligibility
Step1

Complete a quick form online. We'll review it and confirm your pre-eligibility.

Submit your application
Complete your labs
and meet your doctor
Step2

Get simple lab work done, then meet a provider online to finalize your plan.

Your hormone results
Get your medication
delivered at home
Step3

Once approved, your prescription ships directly to your door, fast and free.

Medication delivered at home
Receive 24/7 support
and ongoing care
Step4

Regular check-ins and on-demand medical support to keep you on track.

24/7 support and ongoing care
Sexual wellness

Rediscover desire and intimacy

Physician-guided support for arousal, desire, and comfort, personalized to you.

Get Started

Backed by physicians you can trust

Dr. Jillian Foglesong Stabile, Sipra Medical Reviewer
Sipra Medical Reviewer

“Menopause care is not one-size-fits-all. What matters is matching the right hormone, dose, and route to your symptoms and history, then following up as your body changes.”

Dr. Jillian Foglesong StabileMD, FAAFP, DABOM

Board-certified family physician and Diplomate of the American Board of Obesity Medicine.

American Board of Family Medicine
American Board of Obesity Medicine
Wake Forest University School of Medicine

The pharmacy behind your treatment

Get startedCheck eligibility

Licensed 503A pharmacy

Your treatment ships to all 50 states

Compounded in the USA

Made for you, never mass-produced

Tested before it ships

Sterility, endotoxin, and potency, under USP 795 and 797

Independently accredited

URAC, ACHC, and LegitScript

Women's health questions, answered

Perimenopause is the transition, often starting in your mid-40s, when hormones fluctuate and symptoms begin. Menopause is one year with no period, on average around age 51. You do not need to know which stage you are in; your intake and clinician sort that out.

The 2002 study that raised concern used older formulations and studied women on average a decade past menopause. For many women, especially when started within about ten years of menopause, the benefits outweigh the risks, and in 2025 the FDA removed the boxed warning from menopausal hormone therapy. Your clinician reviews your personal and family history before prescribing.

Each suits different needs. The transdermal options, cream and patch, do not carry the clot risk associated with oral estrogen, and the pill is the simplest routine. Your clinician recommends the format that fits your health and preferences.

Hot flashes and sleep often improve within two to four weeks, with fuller relief by about three months. Individual results vary.

Bioidentical means the hormone is molecularly identical to the one your body makes. The estradiol and progesterone we use are bioidentical. Bioidentical alone does not mean safer; what matters is the right hormone, dose, and route for you, decided with your clinician.

If you have a uterus, progesterone protects the uterine lining when you take estrogen. Women without a uterus may take estrogen alone. Your clinician determines what you need.

Testosterone may be prescribed off-label for low sexual desire in menopausal women. There is no FDA-approved testosterone product for women, and major menopause and sexual-health societies recognize its role for low desire. Your clinician decides whether it is appropriate for you.

It may not be right with a history of breast, uterine, or ovarian cancer, blood clots, stroke, or certain liver or heart conditions. Screening for this is exactly what the medical review is for.

Newer guidance treats duration as a shared decision with your provider based on your symptoms and health, not an arbitrary cutoff age. You and your clinician revisit it over time.

From $79 a month, with plan options and pay-over-time available. You are not charged until a clinician approves your treatment, and there are no hidden fees. State availability is confirmed during your intake.

Your hormones deserve better than guesswork

  • Online visits with licensed physicians
  • Estradiol, progesterone, HRT & sexual wellness
  • Lab fees are included, no surprises
  • FSA & HSA eligible with all plans
Learn moreCheck eligibility
A smiling woman with dark hair in a cream sweater
From$89/mo
+ Sipra membership*

*Price includes medication only. Active $99/mo Sipra membership required.

Health insights worth reading

Physician reviewed, grounded in the most recent studies.

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Menopause and perimenopause: what changes, when, and what actually helps
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