Vaginal dryness relief

In stock

CompoundedVaginal estradiolLocal estrogen for dryness

From$99/mo^*

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* Cream, in 3, 6 or 12 month plans. Prices may vary.

Compounded in the USAFSA and HSA eligiblePay over time with Klarna

Local estrogen for dryness and comfort
Same-day doctor visits and prescriptions
Free expedited shipping, all 50 states
No hidden fees, no surprise charges

A low-dose estrogen cream applied locally to relieve vaginal dryness, irritation, and discomfort during intimacy, with very little absorbed into the rest of the body.

Who it's for: Women with vaginal dryness, irritation, or painful intimacy, especially during or after menopause.

Estradiol, restores estrogen to vaginal tissue locally

A 24/7 care team, day or night
Physician visits and follow-ups
Dose adjusted as you progress
Help with side effects
Medication from a US pharmacy
Free expedited shipping, all 50 states

You can cancel your treatment plan anytime from your online patient portal. There are no cancellation fees.

Note that canceling in the portal does not cancel any active orders already sent to the pharmacy. If your order is pending, contact us at [email protected] and we will help.

The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve any compounded medications for safety or effectiveness.

Important Safety Information (opens in a new tab)

Explore women's treatments

Hormone therapy and targeted add-ons, prescribed and monitored by licensed clinicians.

Vaginal estradiolLocal estrogen for drynessFrom $99/mo

Vaginal health Important Safety Information (opens in a new tab)

DHEA creamVaginal DHEA for comfortFrom $85/mo

Vaginal health Important Safety Information (opens in a new tab)

Two creams, one place

Both work right where the change happens. One adds a little estrogen back, the other helps the tissue make its own.

Compounded

Vaginal estradiolFrom $99/mo

Best for: Dryness, pain with sex, or bladder symptoms.

ContainsA small dose of estradiol, right where it is needed. Very little reaches the blood.

How oftenNightly, then twice a week

FormCream with applicator

Get started

Compounded

DHEA creamFrom $85/mo

Best for: An estrogen-free option.

ContainsDHEA. No estrogen in the tube; the tissue turns it into what it needs.

How oftenEvery night

FormCream with applicator

Get started

Personalized medicine,
in three simple steps

Get started See treatments

Submit your application
and meet with a doctor

Step1

Complete a quick form and meet a licensed provider 100% online. They'll see if a treatment plan is right for you.

Choosing what you are interested in on the Sipra intake

Get your medication
delivered at home

Step2

Once approved, your prescription ships directly to your door, fast and free.

Receive 24/7 support
and ongoing care

Step3

Regular check-ins and on-demand medical support to keep you on track.

Start here · one question

How long have you been experiencing menopause symptoms?

Tap an answer to start your hormone therapy intake. You can change it there.

More than a prescription

Most online programs ship a box. Sipra stays with you.

Sipra compared with a typical online program
		Typical online programs
No membership fee	No fee	Often a monthly fee
The Sipra PromisePay only if a physician approves.	$0 today	Often charged at checkout
Leave anytimeCancel online. No call, no form.	Anytime	Steps may vary
One price, shipping includedVisits and support too.	Included	Fees may vary
US-licensed pharmaciesURAC, ACHC and LegitScript accredited	Accredited	May vary
Tested before it shipsPotency, plus sterility for injections	Yes	Testing may vary
Dosing set by your physician	Included	Follow-up may be limited
Side effect support	Included	May vary
Care team messaging, day or night	Anytime	Hours may be limited

Start my visit

Nothing is charged until a physician approvesFSA and HSA eligible

Not just dryness

After menopause, the tissue itself changes. It is common, and it is treatable.

DrynessPain with sexBurning or itchingNeeding to go more oftenRepeat bladder infections

Estrogen dropsOvaries

The ovaries make less, and the tissue that depends on it changes.

Tissue gets thinnerVagina

Vaginal tissue gets thinner, drier and less elastic.

The bladder feels it tooBladder

The same tissue lines the urethra, so urgency and infections can follow.

Local treatment, local effectApplied here

A cream applied right there treats the tissue where it lives.

Your first six weeks

Both go on at bedtime, on the schedule your clinician sets. Estradiol usually eases to twice a week after two weeks.

Week 1Week 2Week 3Week 4Week 5Week 6

Vaginal estradiolNightly, then twice a week

Every nightTwice a week

DHEA creamThe same every night

Every night

1Fill the applicator

Screw it onto the tube and fill it to the dose on your label.

2At bedtime

Lying down, insert it gently. Overnight, the cream stays where it is needed.

3Rinse and store

Wash the applicator in warm, soapy water and let it dry.

Heard from our members

Real members, in their own words, on what changed after their first visit.

I almost skipped the hardest question.

Dryness and discomfort were hard enough without feeling embarrassed to ask for help. I nearly skipped those questions. Sipra asked them so naturally that I felt comfortable being honest. The doctor explained what could be happening and walked me through my options. I left feeling heard, instead of feeling like this was something I just had to put up with.

Rebecca L. · ArizonaTreated with Vaginal estradiol

Verified member

I understood my choices.

I’d read enough online to know there were options, but I couldn’t tell what the differences meant for me. The doctor explained them in words I understood and made room for my questions. I didn’t feel rushed to choose something before I understood it.

Laura M. · OregonTreated with DHEA cream

Verified member

It wasn’t just something to put up with.

I thought dryness after menopause was simply part of getting older. The doctor explained what was happening to the tissue and that there were ways to help.

Carol H. · FloridaTreated with Vaginal estradiol

Verified member

I could ask about estrogen honestly.

I had worries about using estrogen. The doctor explained how little reaches the bloodstream with a local cream, and also offered an option without estrogen.

Deborah N. · MassachusettsTreated with DHEA cream

Verified member

The bladder part was connected.

I didn’t realize my bladder symptoms and dryness could be related. The questions asked about both, and the doctor explained the link.

Nancy P. · ArizonaTreated with Vaginal estradiol

Verified member

The schedule was easy to follow.

The doctor explained how often to use it at the start and how that changes after a couple of weeks. Clear, simple, written down in my account.

Ellen W. · PennsylvaniaTreated with Vaginal estradiol

Verified member

Typing it was easier than saying it.

I couldn’t have said these things to someone across a desk. Answering privately, in my own time, let me be completely honest.

Margaret S. · OregonTreated with DHEA cream

Verified member

My doctor at home never asked.

I’d had the same symptoms for years and nobody had brought them up. Here, it was one of the first questions, asked kindly.

Joan R. · MichiganTreated with Vaginal estradiol

Verified member

I got a straight answer about safety.

I asked whether it was safe with my history. The doctor gave me a clear, careful answer and explained what would make it a no.

Barbara L. · VirginiaTreated with DHEA cream

Verified member

I knew who to ask afterward.

A small question came up a week in. I messaged from my account and the reply was quick and kind.

Susan T. · TexasTreated with Vaginal estradiol

Verified member

The pharmacy behind your treatment

Get started See treatments

Licensed 503A pharmacy

Your treatment ships to all 50 states

Compounded in the USA

Made for you, never mass-produced

Tested before it ships

Sterility, endotoxin, and potency, under USP 795 and 797

Independently accredited

URAC, ACHC, and LegitScript

From your visit to your door

Exactly what happens after your visit, who handles it, and when you pay. Nothing is charged until a physician approves.

Start my visit

01Online visit
A few questions, no charge
02Physician review
A licensed US physician
03Approval
Charged only if approved
04Pharmacy
Prepared in the US
05Delivery
Expedited shipping included
06Ongoing care
Check-ins and dose changes

Start my visit

Sipra Medical Reviewer

“Vaginal dryness after menopause is common and very treatable. What matters is treating the tissue itself, gently and locally, and checking in as it recovers.”

Dr. Jillian Foglesong StabileMD, FAAFP, DABOM

Board-certified family physician and Diplomate of the American Board of Obesity Medicine.

American Board of Family Medicine

American Board of Obesity Medicine

Wake Forest University School of Medicine

Vaginal health questions, answered

It is a group of changes that come with lower estrogen, including vaginal dryness, burning, pain with sex, and urinary urgency or frequent urinary infections. Unlike hot flashes, these symptoms often get worse over time without treatment. It is very common, and it is treatable.

Vaginal estradiol is a low-dose estrogen that works mostly right where it is applied. Vaginal DHEA is a hormone that the tissue converts into estrogen and related hormones locally. Your physician chooses between them based on your history.

Lubricants and moisturizers add moisture for a short time, but they do not change the tissue itself. Local hormone treatment helps the tissue become thicker and more elastic over time. Many women use both.

Many women notice some relief in a few weeks, with fuller change over a few months. It can take longer for pain with sex to improve. Individual results vary.

Some women notice local irritation, discharge, or spotting, especially early on. Because the dose is low and works locally, less reaches the rest of the body than with oral estrogen. Tell your care team about anything new, and report any unexpected vaginal bleeding.

Women with unexplained vaginal bleeding, certain hormone-sensitive cancers, or a history of blood clots may not be a fit. If you have had breast cancer, your physician may want input from your oncologist. Your physician reviews your full history first.

A compounded medication is prepared by a licensed pharmacy for a specific patient. Compounded medications are not FDA-approved, and they are not the same as any brand-name product. Your plan shows what you receive, and it ships from a licensed US 503A pharmacy that tests it first.

No office visit is needed to start. A licensed US physician reviews your online intake and symptoms. If they think an in-person exam is needed, they will tell you.

Plans are billed per plan term, and the price does not change with your dose. Shipping is included, and you pay nothing unless a physician approves your treatment. It is cash pay with no insurance needed, and FSA and HSA funds can be used.

Yes. You can cancel online at any time, with no phone call and no form. These symptoms tend to return after treatment stops, so message your care team first to talk through your options.