Chapter 01 · The molecules
One target versus two
Semaglutide acts on a single receptor, GLP-1, a hormone that helps regulate appetite and slow gastric emptying. Tirzepatide acts on two receptors, GIP and GLP-1, which is why it is described as a dual agonist. Both are taken as a once-weekly injection, and both are used together with diet and activity rather than on their own.
*12 month plan, billed once for the term when a physician approves. Renews each term.
How much weight a person loses differs by medication, dose and the person. A physician decides which fits you, and no result is promised. Individual results vary.
Chapter 02 · Who decides
Why the choice is clinical
Cost, side effect tolerance, other medical conditions, and how your body responds all factor into which medication fits you, and they can point in different directions. To be clear about who does what: sipra connects you with US-licensed physicians who decide whether a medication is appropriate for you. We are not the compounder. Compounded medications are prepared by a licensed 503A pharmacy under a physician's patient-specific prescription; they are not FDA-approved and are not equivalent to the brand-name products.1
Start here · one question
What's your goal weight?
Choose a goal to discuss with your clinician. You can change it in your intake.
The exact FDA-approved product and condition also matter. Some brand-name versions are approved for other conditions, such as obstructive sleep apnea2 or MASH liver disease.3 Compounded medications are not FDA-approved for any use. These labeled uses do not make either medication the automatic choice for a person. A licensed physician weighs the diagnosis, full history, contraindications, coverage, and exact product before recommending treatment.
This comparison is educational. It does not say one medication is better for you; a licensed physician weighs your history and goals and makes that call. Individual results vary.
