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Personalize GLP-1 treatments

In stockCompounded semaglutide vialCompounded tirzepatide vial
CompoundedSemaglutide
From$79/mo

+ Sipra membership*

Get Started

* Medication only. A $99/mo Sipra membership is billed separately.
Injectable, microdose or oral, in 1, 3 or 6 month plans. Prices may vary.

Compounded in the USAFSA and HSA eligiblePay over time withKlarnaAfterpayAffirm
  • Same price at every dose
  • Same-day doctor visits and prescriptions
  • Free expedited shipping, all 50 states
  • 24/7 personalized care

GLP-1 medications may be preferred over other weight loss drugs because they are non-stimulant, which reduces the risk of side effects linked to stimulant medications. Unlike stimulants such as phentermine, GLP-1s may aid weight loss while also improving blood sugar control. The right medication depends on your health profile. Start your free telehealth consultation to discuss your options with a licensed provider.

Both are GLP-1 medications that quiet appetite and slow how fast your stomach empties. Semaglutide is a single agonist, acting on the GLP-1 receptor. Tirzepatide is a dual agonist, acting on the GLP-1 and GIP receptors, so it targets a second pathway involved in appetite and blood sugar. In clinical trials, these treatments averaged around 15% to 20% body-weight reduction, depending on the medication and dose. A licensed provider helps choose the option that fits your health and goals.

Figures are clinical-trial averages. Individual results vary.

Every Sipra plan is built around you. You will receive a personalized treatment plan created by a licensed medical provider after a full review of your health profile. If medication is right for you, we will craft a custom dosing schedule and ship your treatment straight to your door through a certified, state-licensed pharmacy. You will also get unlimited 24/7 messaging with your dedicated care team, so you are supported every step of the way.

The membership is what turns a prescription into ongoing care. It covers your licensed provider, your follow-up visits, unlimited 24/7 messaging with your care team, and the dose adjustments and monitoring that keep treatment working and safe over time. One membership covers unlimited visits across every treatment you are on, so if you add another medication later, you save instead of paying a second set of fees. We keep it separate from the medication on purpose, so your care is funded transparently and you never pay a hidden markup buried in the price of your drug.

You can cancel your treatment plan anytime from your online patient portal. There are no cancellation fees. Note that canceling in the portal does not cancel any active orders already sent to the pharmacy. If your order is pending, contact us at [email protected] and we will help.

The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve any compounded medications for safety or effectiveness.

Important Safety Information (opens in a new tab)

Explore weight-loss treatments

Compounded GLP-1 medications, prescribed and monitored by licensed clinicians.

Compounded Semaglutide — Injection
Compounded Semaglutide — InjectionWeekly injection, B12 for energyFrom $79/mo
Injectable
Important Safety Information (opens in a new tab)
Compounded Tirzepatide — Injection
Compounded Tirzepatide — InjectionDual-action weekly injection, B12 for energyFrom $179/mo
Injectable
Important Safety Information (opens in a new tab)
Compounded Semaglutide — Oral ODT
Compounded Semaglutide — Oral ODTDissolvable semaglutide, B6 eases nauseaFrom $179/mo
Oral
Important Safety Information (opens in a new tab)
Compounded Tirzepatide — Oral ODT
Compounded Tirzepatide — Oral ODTDissolvable tirzepatide, no needlesFrom $279/mo
Oral
Important Safety Information (opens in a new tab)
Compounded Semaglutide Microdose — Injection
Compounded Semaglutide Microdose — InjectionLow-dose weekly start, B12 for energyFrom $79/mo
Microdose
Important Safety Information (opens in a new tab)
Compounded Tirzepatide Microdose — Injection
Compounded Tirzepatide Microdose — InjectionLow-dose dual-action start, B12From $179/mo
Microdose
Important Safety Information (opens in a new tab)
Anti-nausea
Anti-nauseaOndansetron for nausea, as needed
GLP-1 support
Important Safety Information (opens in a new tab)
Constipation relief
Constipation reliefA gentle laxative for GLP-1 constipation
GLP-1 support
Important Safety Information (opens in a new tab)

Personalized medicine,
in three simple steps

Get startedCheck eligibility
Submit your application
and meet with a doctor
Step1

Complete a quick form and meet a licensed provider 100% online. They'll see if a treatment plan is right for you.

Submit your application
Get your medication
delivered at home
Step2

Once approved, your prescription ships directly to your door, fast and free.

Medication delivered at home
Receive 24/7 support
and ongoing care
Step3

Regular check-ins and on-demand medical support to keep you on track.

24/7 support and ongoing care

How GLP-1 works

A silver anatomical figure with the brain, heart, liver, pancreas, and gut highlighted.

Quiets hunger and cravings.

Brain

Acts on the brain's appetite center; in trials, semaglutide lowered hunger and calorie intake.

Linked to lower heart risk in trials.

Heart

In the SELECT trial, semaglutide reduced major cardiac events in adults with excess weight and heart disease.

Helps balance glucose and fat.

Liver

Lowers the liver's glucose output; semaglutide improved liver disease (MASH) in a phase 3 trial.

Steadies your blood sugar.

Pancreas

Prompts insulin as blood sugar rises; GLP-1 medications lowered A1c in diabetes trials.

Keeps you full longer.

Gut

Slows gastric emptying, so fullness lasts, as seen in obesity studies.

Based on clinical trials of GLP-1 medications. Individual results vary.

The pharmacy behind your treatment

Get startedCheck eligibility

Licensed 503A pharmacy

Your treatment ships to all 50 states

Compounded in the USA

Made for you, never mass-produced

Tested before it ships

Sterility, endotoxin, and potency, under USP 795 and 797

Independently accredited

URAC, ACHC, and LegitScript

Dr. Jillian Foglesong Stabile, Sipra Medical Reviewer
Sipra Medical Reviewer

“Good health is rarely about a single number or a single prescription. It is about looking at the whole picture, your metabolism, your labs, your energy, and your history, with a physician who keeps watching as things change.”

Dr. Jillian Foglesong StabileMD, FAAFP, DABOM

Board-certified family physician and Diplomate of the American Board of Obesity Medicine.

American Board of Family Medicine
American Board of Obesity Medicine
Wake Forest University School of Medicine

Weight loss questions, answered

Most adults qualify based on BMI and health history, not the number on the scale alone. You answer a few questions online, and a licensed physician reviews your intake before anything is prescribed. There is no charge until a physician approves your treatment, so it costs nothing to find out.

Both are GLP-1 based medications, and your physician recommends the one that fits your health history and goals. If needles are a concern, a daily oral option is available where appropriate. They work by slowing how quickly your stomach empties and easing appetite signals, and the choice is a clinical decision made with you, not something you sort out alone.

The first weeks are mostly your body adjusting while your physician steps up the dose, so think of them as the runway, not the result. Meaningful change tends to show up over months, not days. In clinical trials these medications produced significant average weight loss with consistent use, though individual results vary.

Most side effects are digestive, usually mild to moderate, and tend to ease as your body adjusts, with nausea the most common. Simple habits help, like smaller meals, eating slowly, and staying hydrated. Your care team is reachable when symptoms come up, and your physician can adjust your plan, so you are not managing it on your own.

Any significant weight loss can include some muscle, which is why protein, regular movement and strength work, and a gradual physician-managed dose matter. Your care team can talk through habits that help you preserve muscle while you lose fat. Individual results vary.

GLP-1 medications have been studied in large clinical trials, and a licensed physician reviews your full history, including your other medications and conditions, before prescribing. The compounded versions we offer are prepared by a licensed US pharmacy to your prescription and are not FDA-approved. They are not right for everyone, including some people with certain thyroid cancers, a history of pancreatitis, or who are pregnant or breastfeeding, and your physician makes that call with you. That medical review is exactly why it comes first.

A compounded GLP-1 is a patient-specific preparation made by a licensed US pharmacy to your individual prescription. It is its own distinct medication, not a generic and not equivalent to Wegovy®, Ozempic®, Mounjaro®, or Zepbound®, and compounded medications are not FDA-approved. Your physician decides whether a branded or compounded option is right for you, and you always know which one you are receiving before it ships.

You see the full cost before you ever pay, with no hidden fees and no surprise charges. You pay per shipment, and your membership includes physician follow-up and ongoing support. Sipra is cash-pay, so you do not need insurance, and many members use HSA or FSA funds. You are not charged until a physician approves your treatment.

There is no fixed time you must stay on a GLP-1. Some people taper or pause once they reach their goal, and others continue on a maintenance dose, your physician helps you decide based on how your body responds. Weight can return if earlier habits return, so your plan pairs the medication with changes meant to last, and your care team stays with you through that. Individual results vary.

This is where Sipra is different. A licensed physician prescribes and follows up, and your care team answers questions and adjusts your plan as your body responds, included, not an add-on. Plenty of programs hand you a prescription and little after. Sipra stays with you, from your first dose through every refill.

Lose weight with a plan made just for you

  • Same-day doctor visits and prescriptions
  • Semaglutide, tirzepatide & other GLP-1s
  • FSA & HSA eligible with all plans
Learn moreCheck eligibility
A smiling woman with wavy dark hair in a cream top
From$79/mo
+ Sipra membership*

*Price includes medication only. Active $99/mo Sipra membership required.

Health insights worth reading

Physician reviewed, grounded in the most recent studies.

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GLP-1 weight loss 101: how semaglutide and tirzepatide actually work
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