Hormone therapy

In stock

CompoundedHRT CreamBiest estradiol and estriol, applied daily

From$95/mo

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Compounded in the USAFSA and HSA eligiblePay over time with Klarna

Personalized hormone therapy
Clinician-reviewed and monitored
24/7 support
No hidden fees, no surprise charges

HRT cream is a compounded Bi-Est cream of estradiol and estriol, applied to the skin daily to ease menopause symptoms.

Who it's for: Women in perimenopause or menopause with hot flashes, night sweats, poor sleep or mood changes who want an option other than a daily pill.

EstradiolHalf the Bi-Est blend, for menopause symptom relief
EstriolThe other half of the Bi-Est blend, a gentler estrogen

HRT CreamCream

Topical estradiol for menopause symptoms
Women in perimenopause or menopause who want symptom relief without a daily pill.

Estradiol OralTablet

Daily oral estradiol for hormone balance
Women who prefer a simple daily pill for menopause symptoms.

Estradiol PatchPatch

Transdermal estradiol, changed twice weekly
Women who want steady levels and a twice-weekly routine instead of a daily pill.

Your clinician helps you choose.

A 24/7 care team, day or night
Physician visits and follow-ups
Dose adjusted as you progress
Help with side effects
Medication from a US pharmacy
Free expedited shipping, all 50 states

You can cancel your treatment plan anytime from your online patient portal. There are no cancellation fees.

Note that canceling in the portal does not cancel any active orders already sent to the pharmacy. If your order is pending, contact us at support@sipra.com and we will help.

The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve any compounded medications for safety or effectiveness.

Important Safety Information (opens in a new tab)

Explore women's treatments

Hormone therapy and targeted add-ons, prescribed and monitored by licensed clinicians.

HRT CreamBiest estradiol and estriol, applied dailyFrom $95/mo

HRT Important Safety Information (opens in a new tab)

Estradiol OralDaily oral estradiol for hormone balanceFrom $190/mo

HRT Important Safety Information (opens in a new tab)

Estradiol PatchTransdermal estradiol, changed twice weeklyFrom $390/mo

HRT Important Safety Information (opens in a new tab)

Testosterone CreamLow-dose testosterone for energy and libido

Coming SoonHRT Important Safety Information (opens in a new tab)

Cream, pill or patch

Cream, pill or patch, in the rhythm that fits your week. Your clinician sets the dose.

Compounded

HRT creamFrom $95/mo

Steady hormone levels through the skin, with no daily pill.

FormCream

RhythmEvery morningMTWTFSS

ContainsEstradiol, estriol

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Prescription

Estradiol oralFrom $190/mo

One tablet a day, with progesterone included.

FormOral tablet

RhythmOne pill a dayMTWTFSS

ContainsEstradiol, progesterone

Get started

Prescription

Estradiol patchFrom $390/mo

Steady estradiol through the skin, changed twice a week.

FormPatch

RhythmTwice a weekMTWTFSS

ContainsEstradiol

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Compounded

ProgesteroneFrom $85/mo

Balances estrogen and supports sleep.

FormCapsule

RhythmEvery nightMTWTFSS

ContainsProgesterone

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Personalized medicine,
in three simple steps

Get started Check eligibility

Submit your application
and meet with a doctor

Step1

Complete a quick form and meet a licensed provider 100% online. They'll see if a treatment plan is right for you.

Choosing what you are interested in on the Sipra intake

Get your medication
delivered at home

Step2

Once approved, your prescription ships directly to your door, fast and free.

Receive 24/7 support
and ongoing care

Step3

Regular check-ins and on-demand medical support to keep you on track.

Start here · one question

How long have you been experiencing menopause symptoms?

Tap an answer to start your hormone therapy intake. You can change it there.

More than a prescription

Most online programs ship a box. Sipra stays with you.

Sipra compared with a typical online program
		Typical online programs
No membership fee	No fee	Often a monthly fee
The Sipra PromisePay only if a physician approves.	$0 today	Often charged at checkout
Leave anytimeCancel online. No call, no form.	Anytime	Steps may vary
One price, shipping includedVisits and support too.	Included	Fees may vary
US-licensed pharmaciesURAC, ACHC and LegitScript accredited	Accredited	May vary
Tested before it shipsPotency, plus sterility for injections	Yes	Testing may vary
Dosing set by your physician	Included	Follow-up may be limited
Side effect support	Included	May vary
Care team messaging, day or night	Anytime	Hours may be limited

Start my visit

Nothing is charged until a physician approvesFSA and HSA eligible

Where menopause shows up

Menopause touches more than hot flashes. Here is where it shows up, and how treatment reaches each place.

Hot flashes and sleepBrain

Lower estrogen unsettles the brain’s heat control. Hot flashes, night sweats and broken sleep follow.

Cream and patch skip a stepSkin

Through the skin, hormones reach the blood without the liver’s first pass.

Tissue gets thinnerPelvis

Vaginal and bladder tissue dry and thin without estrogen.

Bone thins fasterBone

Estrogen helps hold on to bone. Replacing it helps protect it.

How relief usually unfolds

Relief comes in waves. Sleep often returns first, and dryness takes the longest.

Week 1Week 4Month 2Month 3 and on

Sleep

Hot flashes

Mood

Dryness

Libido

Heard from our members

Real members, in their own words, on what changed after their first visit.

I didn’t have to convince anyone.

I wasn’t sleeping, hot flashes caught me off guard, and I kept losing words mid-sentence. Separately, none of it sounded like much. Together, it was affecting my whole day. At Sipra, the doctor asked about all of it. I didn’t have to convince anyone something was wrong. Having someone take the whole picture seriously was such a relief.

Michelle A. · CaliforniaTreated with HRT cream

Verified member

Someone connected the dots.

Night sweats, poor sleep, short temper. I’d been treating each one on its own. The doctor asked about all of it together and explained how they were linked.

Julie M. · TexasTreated with Estradiol patch

Verified member

I wasn’t told to wait it out.

Two people had told me it would pass. The doctor took my symptoms seriously and walked me through options, risks included, so I could decide.

Cheryl B. · OhioTreated with HRT cream

Verified member

My history mattered.

My mother had breast cancer, so I came in worried. The doctor asked detailed questions about my family history and explained what that meant for my choices.

Monica R. · FloridaTreated with Progesterone

Verified member

A cream fit my life better.

I didn’t want another pill. The doctor explained the forms side by side, and a cream I could fit into my evening routine was the right call for me.

Laura G. · ColoradoTreated with HRT cream

Verified member

The check-ins kept things on track.

At my check-in the doctor asked what had changed and adjusted the plan. It felt like ongoing care, not a one time prescription.

Patricia W. · WashingtonTreated with Estradiol oral

Verified member

Sleep was the first thing I mentioned.

I hadn’t slept through the night in months. The doctor listened, asked about my routine and explained what progesterone at bedtime is meant to do.

Tina L. · GeorgiaTreated with Progesterone

Verified member

Brain fog was taken seriously.

I was losing words in meetings and thought it was just stress. The doctor asked about it alongside everything else and didn’t dismiss it.

Sandra K. · IllinoisTreated with Estradiol oral

Verified member

I could ask between visits.

A question about a missed dose came up on a weekend. I sent a message and had a clear answer quickly.

Angela D. · North CarolinaTreated with Estradiol patch

Verified member

Perimenopause counted too.

I’m still having periods, so I assumed I was too early. The doctor explained perimenopause and why my symptoms still counted.

Kristen J. · MinnesotaTreated with HRT cream

Verified member

The pharmacy behind your treatment

Get started Check eligibility

Licensed 503A pharmacy

Your treatment ships to all 50 states

Compounded in the USA

Made for you, never mass-produced

Tested before it ships

Sterility, endotoxin, and potency, under USP 795 and 797

Independently accredited

URAC, ACHC, and LegitScript

From your visit to your door

Exactly what happens after your visit, who handles it, and when you pay. Nothing is charged until a physician approves.

Start my visit

01Online visit
A few questions, no charge
02Physician review
A licensed US physician
03Approval
Charged only if approved
04Pharmacy
Prepared in the US
05Delivery
Expedited shipping included
06Ongoing care
Check-ins and dose changes

Start my visit

Sipra Medical Reviewer

“Menopause care is not one-size-fits-all. What matters is matching the right hormone, dose, and route to your symptoms and history, then following up as your body changes.”

Dr. Jillian Foglesong StabileMD, FAAFP, DABOM

Board-certified family physician and Diplomate of the American Board of Obesity Medicine.

American Board of Family Medicine

American Board of Obesity Medicine

Wake Forest University School of Medicine

Hormone therapy questions, answered

As estrogen and progesterone fall during perimenopause and menopause, hormone therapy replaces some of what your body is making less of. It is most often used for hot flashes, night sweats, sleep trouble, and vaginal dryness. Your physician decides if it is a fit for you.

Each form has a different routine and a different way into the body. Pills are the simplest to take. Patches and creams absorb through the skin, and some people prefer them because they skip the liver. Your physician recommends a form based on your health and preferences.

If you still have a uterus, estrogen taken alone can thicken the uterine lining over time. Progesterone helps protect it. Your physician decides whether you need it based on your history.

Many women notice changes in hot flashes and sleep within a few weeks. Fuller relief can take a few months. Individual results vary, and your physician can adjust your plan.

Common effects include breast tenderness, bloating, headache, nausea, and spotting, which often ease as your body adjusts. Hormone therapy can also raise the risk of blood clots and some other conditions for certain women. Tell your care team about anything new, and report sudden chest pain, leg swelling, or severe headache right away.

Women with a history of breast cancer, blood clots, stroke, unexplained vaginal bleeding, or certain liver disease are generally not a fit. Age and how long since your last period also matter. Your physician reviews your full history and makes the call.

A compounded medication is prepared by a licensed pharmacy for a specific patient. Compounded medications are not FDA-approved, and they are not the same as any brand-name product. Your plan shows exactly what you are receiving, and it ships from a licensed US 503A pharmacy that tests it first.

No office visit is needed to start. A licensed US physician reviews your online intake, including your symptoms and history. If they want labs or a recent mammogram on file, they will tell you.

Your price does not change with your dose. Shipping is included, and you pay nothing unless a physician approves your treatment. It is cash pay with no insurance needed, and FSA and HSA funds can be used.

Yes. You can cancel online at any time, with no phone call and no form. If you stop, symptoms may return, so message your care team first and your physician can help you taper or change your plan.