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Needle-free GLP-1 melts

In stockCompounded semaglutide dissolving tabletsCompounded tirzepatide dissolving tablets
CompoundedSemaMelt
From$199/mo*
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* Oral, in 3, 6 or 12 month plans. Prices may vary.

Compounded in the USAFSA and HSA eligiblePay over time withKlarnaAfterpayAffirm
  • Same price at every dose
  • Same-day doctor visits and prescriptions
  • Free expedited shipping, all 50 states
  • 24/7 personalized care

A daily semaglutide tablet that dissolves under the tongue, with vitamin B6.

GLP-1 medications are not stimulants, which lowers the risk of the side effects linked to stimulant weight-loss drugs. They may also help with blood sugar control.

SemaMeltSingle agonist
  • Works on one appetite hormone
  • Often a first pick for a sensitive stomach
TirzaMeltDual agonist
  • Works on two appetite hormones
  • Often chosen when blood sugar is a focus

Switching from one to the other starts again at the lowest dose. Your physician helps you choose.

  • A 24/7 care team, day or night
  • A personal action plan to your goal
  • Physician visits and follow-ups
  • Dose adjusted as you progress
  • Help with side effects
  • Medication from a US pharmacy
  1. Online visitA few questions, no charge
  2. Physician reviewA licensed US physician
  3. ApprovalCharged only if approved
  4. PharmacyPrepared in the US
  5. DeliveryExpedited shipping included
  6. Ongoing careCheck-ins and dose changes

Cancel anytime, online in your account. No call, no form, no fee.

Canceling does not stop an order already sent to the pharmacy. If one is on its way, write to [email protected] and we will help.

Explore weight-loss treatments

Compounded GLP-1 medications, prescribed and monitored by licensed clinicians.

See your path to your goal

Enter your height and weight to see how long your goal could take on treatment.

Medication
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Your path on treatment

Your path appears here once you add your numbers.

Personalized medicine,
in three simple steps

Submit your application
and meet with a doctor
Step1

Complete a quick form and meet a licensed provider 100% online. They'll see if a treatment plan is right for you.

Submit your application
Get your medication
delivered at home
Step2

Once approved, your prescription ships directly to your door, fast and free.

Medication delivered at home
Receive 24/7 support
and ongoing care
Step3

Regular check-ins and on-demand medical support to keep you on track.

24/7 support and ongoing care
sipra
Start here · one question
How much weight do you want to lose?
Tap an answer to start your online visit. Nothing is charged unless a physician approves.

More than a prescription

Most online programs ship a box. Sipra stays with you.

Sipra compared with a typical online program
sipraTypical online programs
No membership feeNo feeOften a monthly fee
The Sipra PromisePay only if a physician approves.$0 todayOften charged at checkout
Leave anytimeCancel online. No call, no form.AnytimeSteps may vary
One price, shipping includedVisits and support too.IncludedFees may vary
US-licensed pharmaciesURAC, ACHC and LegitScript accreditedAccreditedMay vary
Tested before it shipsPotency, plus sterility for injectionsYesTesting may vary
Dosing set by your physicianIncludedFollow-up may be limited
Side effect supportIncludedMay vary
Care team messaging, day or nightAnytimeHours may be limited
Start my visit

Nothing is charged until a physician approvesFSA and HSA eligible

How GLP-1 works

A silver anatomical figure with the brain, heart, liver, pancreas, and gut highlighted.

Quiets hunger and cravings.

Brain

Acts on the brain's appetite center; in trials, semaglutide lowered hunger and calorie intake.

Linked to lower heart risk in trials.

Heart

In the SELECT trial, semaglutide reduced major cardiac events in adults with excess weight and heart disease.

Helps balance glucose and fat.

Liver

Lowers the liver's glucose output; semaglutide improved liver disease (MASH) in a phase 3 trial.

Steadies your blood sugar.

Pancreas

Prompts insulin as blood sugar rises; GLP-1 medications lowered A1c in diabetes trials.

Keeps you full longer.

Gut

Slows gastric emptying, so fullness lasts, as seen in obesity studies.

Based on clinical trials of GLP-1 medications. Individual results vary.

The pharmacy behind your treatment

Licensed 503A pharmacy

Your treatment ships to all 50 states

Compounded in the USA

Made for you, never mass-produced

Tested before it ships

Sterility, endotoxin, and potency, under USP 795 and 797

Independently accredited

URAC, ACHC, and LegitScript

From your visit to your door

Exactly what happens after your visit, who handles it, and when you pay. Nothing is charged until a physician approves.

Start my visit
  1. 01Online visit

    A few questions, no charge

  2. 02Physician review

    A licensed US physician

  3. 03Approval

    Charged only if approved

  4. 04Pharmacy

    Prepared in the US

  5. 05Delivery

    Expedited shipping included

  6. 06Ongoing care

    Check-ins and dose changes

Dr. Jillian Foglesong Stabile, Sipra Medical Reviewer
Sipra Medical Reviewer

“The science on GLP-1 medications is genuinely strong, but the medicine is only part of it. What matters is whether you have a real plan and a physician who stays with you through the dose changes and the plateaus, because that is where lasting results actually come from.”

Dr. Jillian Foglesong StabileMD, FAAFP, DABOM

Board-certified family physician and Diplomate of the American Board of Obesity Medicine.

American Board of Family Medicine
American Board of Obesity Medicine
Wake Forest University School of Medicine

Weight loss questions, answered

Most adults qualify based on BMI and health history, not the number on the scale alone. You answer a few questions online, and a licensed physician reviews your intake before anything is prescribed.

They are daily compounded tablets that dissolve under the tongue, for people who prefer not to inject. SemaMelt is semaglutide with vitamin B6; TirzaMelt is tirzepatide, which acts on two pathways (GLP-1 and GIP). Take one 30 minutes before food or drink and let it dissolve. Your physician decides whether a melt or an injection fits you better.

The first weeks are mostly your body adjusting while your physician steps up the dose, so think of them as the runway, not the result. Meaningful change tends to show up over months, not days. In clinical trials these medications produced significant average weight loss with consistent use, though individual results vary.

Most side effects are digestive, usually mild to moderate, and tend to ease as your body adjusts, with nausea the most common. Simple habits help, like smaller meals, eating slowly, and staying hydrated. Your care team is reachable when symptoms come up, and your physician can adjust your plan, so you are not managing it on your own.

Any significant weight loss can include some muscle, which is why protein, regular movement and strength work, and a gradual physician-managed dose matter. Your care team can talk through habits that help you preserve muscle while you lose fat. Individual results vary.

GLP-1 medications have been studied in large clinical trials, and a licensed physician reviews your full history, including your other medications and conditions, before prescribing. The compounded versions we offer are prepared by a licensed US pharmacy to your prescription and are not FDA-approved. They are not right for everyone, including some people with certain thyroid cancers, a history of pancreatitis, or who are pregnant or breastfeeding, and your physician makes that call with you. That medical review is exactly why it comes first.

A compounded GLP-1 is a patient-specific preparation made by a licensed US pharmacy to your individual prescription. It is its own distinct medication, not a generic and not the same as any brand-name, FDA-approved medication, and compounded medications are not FDA-approved. Your physician decides whether a branded or compounded option is right for you, and you always know which one you are receiving before it ships.

You see every plan length, its monthly price, and its total before you start, with no hidden fees and no surprise charges. Nothing is charged at checkout: your plan total is charged once, only if a physician approves your treatment, and it includes physician follow-up, ongoing support, and expedited shipping. Sipra is cash-pay, so you do not need insurance, and many members use HSA or FSA funds.

There is no fixed time you must stay on a GLP-1. Some people taper or pause once they reach their goal, and others continue on a maintenance dose, your physician helps you decide based on how your body responds. Weight can return if earlier habits return, so your plan pairs the medication with changes meant to last, and your care team stays with you through that. Individual results vary.

This is where Sipra is different. A licensed physician prescribes and follows up, and your care team answers questions and adjusts your plan as your body responds, included, not an add-on. Plenty of programs hand you a prescription and little after. Sipra stays with you, from your first dose through every refill.

It depends on your history, which is why a licensed physician reviews your intake before anything is prescribed, rather than a checklist deciding on its own. GLP-1 medications are not right for everyone, including some people with certain thyroid cancers, a history of pancreatitis, or who are pregnant or breastfeeding, and your physician makes that call with you.

A state-licensed US pharmacy prepares your medication to your prescription, and it is tested before it ships under USP 795 and 797, including sterility and endotoxin testing for injections. The pharmacies we work with are accredited by URAC, ACHC and LegitScript, and nothing is sent until your physician approves the prescription.

No. Your price is set by your plan length, not your dose, so it stays the same as your physician steps your dose up. If a renewal price ever changes at the end of a plan, we tell you at least 30 days ahead, and you can cancel before paying the new rate.

Yes. Cancel online in your account, with no call and no form. To stop your next order from being prepared, cancel at least 13 days before your current paid period ends. An order already sent to the pharmacy cannot be stopped. Leaving a 6 or 12 month plan early is settled as our Terms describe, and medication not yet sent to the pharmacy is refunded.

Lose weight with a plan made just for you

  • Same-day doctor visits and prescriptions
  • Semaglutide, tirzepatide & other GLP-1s
  • FSA & HSA eligible with all plans
A smiling woman with wavy dark hair in a cream top
From$149/mo

From price shown is the 12-month plan rate. Prices may vary.