Vardenafil


Vardenafil is a prescription PDE5 inhibitor for erectile dysfunction. Its tablet and orally disintegrating tablet formulations have distinct instructions and cannot be assumed interchangeable. Choosing it involves cardiovascular and interaction screening, including a specific discussion of heart-rhythm history and other medicines that can affect electrical conduction. 1
| At a glance | Vardenafil |
|---|---|
| Use | Erectile dysfunction |
| Class | PDE5 inhibitor |
| Form distinction | Conventional and orally disintegrating tablets |
Product and route distinctions
Vardenafil supports erection during sexual stimulation. It is not a treatment for low sexual desire. The dissolving tablet is a defined formulation, not evidence for every compounded capsule or troche containing vardenafil. A catalogue capsule name does not establish equivalence to an approved tablet. 1
Risks to discuss
Nitrates and riociguat are incompatible with PDE5 treatment. Tell the clinician about long-QT syndrome, fainting, heart disease and rhythm medicines. Headache, flushing and indigestion can occur. A prolonged erection or sudden vision or hearing loss requires urgent assessment. 1
A useful medication review
Bring the actual pharmacy label and all other medicines, including ED medicines obtained elsewhere. Ask why this formulation was selected, whether the heart history changes eligibility, and what follow-up will determine whether the prescription remains appropriate.
Heart rhythm and medication history
Vardenafil deserves extra attention in people with congenital long-QT syndrome or medicines that prolong the QT interval. Nitrates, recreational nitrites and riociguat are incompatible because of blood-pressure risk. Alpha blockers and other antihypertensives can also contribute to dizziness or fainting. Bring an actual medication list, including antibiotics, antifungals, HIV medicines and rhythm drugs, because metabolism and rhythm interactions cannot be screened reliably from a general health summary. 1

Tablet formulations are not interchangeable
Conventional vardenafil tablets and orally disintegrating tablets have different instructions and should not be substituted by matching milligrams. A compounded capsule or troche is another distinct formulation. Confirm whether the product is swallowed, allowed to dissolve, or used another way and follow the exact label. If the effect is less than expected, do not repeat the dose early, change formulations or add sildenafil or tadalafil without clinical direction. 1
Urgent symptoms
Seek emergency care for an erection lasting more than four hours. Sudden vision loss, sudden hearing change, fainting, severe chest symptoms or signs of an allergic reaction need urgent assessment. If chest pain occurs after vardenafil, tell emergency personnel the medicine and last-use time before any nitrate is given. Palpitations or a new irregular heartbeat are particularly important when a person has a rhythm history or uses another QT-prolonging drug. 1
What to do after an ineffective dose
An ineffective attempt can reflect timing, food, stimulation, anxiety, alcohol, relationship context or the underlying condition. It does not prove the dose is too low. Record the product and circumstances and discuss several attempts as directed before changing therapy. Repeating early or mixing PDE5 inhibitors can increase headache, low blood pressure and priapism risk without addressing the reason it did not work. Ask whether the underlying cardiovascular risk assessment is current. 1
Frequently asked questions
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Sources
- MedlinePlus: Vardenafil medlineplus.gov