What labs should you get before starting semaglutide or tirzepatide?
There is no universal blood panel every person must buy before semaglutide or tirzepatide. A clinician selects tests based on the indication, medical history, symptoms, current medicines, and existing results. An expensive broad panel is not a substitute for that assessment. 1, 2, 3

Glucose or A1C can help assess diabetes status. Kidney function and other tests may be useful depending on the patient and treatment context. Recent valid results may already answer some questions.
Testing does not determine suitability on its own. The assessment also includes contraindications, relevant symptoms, pregnancy considerations, and medication interactions.
Do the drug labels require the same tests for everyone?
No. Label monitoring instructions depend on context. For example, glucose monitoring is relevant for patients with diabetes, and kidney-function assessment can matter when adverse effects cause volume depletion.
Should I request thyroid tumor blood screening?
Routine calcitonin measurement or thyroid ultrasound is not established as useful screening for all patients taking these medicines. A history of medullary thyroid carcinoma or MEN2 is a separate contraindication question for the prescriber.
What should I ask the clinician?
Ask which tests will change the plan, whether existing results are sufficient, and when follow-up testing is needed. Confirm how results and concerning symptoms will be reviewed.
Bottom line
Choose baseline tests to answer specific clinical questions. The right assessment combines history, appropriate tests, and follow-up.
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