Women's health comparison · Medical comparison
Defy Medical menopause review: cost, care and alternatives
Defy Medical is a concierge telemedicine practice that treats hormone conditions, including menopause. Its menopause page says it has no subscriptions or contracts: you pay for the visits and treatment you use, and order through a patient portal. The pages we checked list no price for women's hormone therapy. Here is how that model compares with Sipra.
At a glance
 | Defy Medical | |
|---|---|---|
| Starting price | Cream from $95/mo, progesterone from $85/mo | No women's price published |
| Medication | Included in the price | Ordered and paid through its portal |
| Subscription | Plan price, membership included | None, pay for what you use |
| Consults | Online | One hour telehealth consults |
| Insurance | Cash price, no insurance billing | No insurance; superbill for out of network claims |
Based on publicly available information as of 2026-10-30. Confirm current details on each company's own site.
What Defy Medical is
Defy Medical is a concierge telemedicine practice. Its hormone therapy page lists injectable, topical, capsule, suppository, and pellet options, and it has a page for menopause care.
Defy's terms refer to the pharmacies that fill its prescriptions. The pages we checked do not name them.
Defy Medical pricing in 2026
Defy's menopause page says it has no subscriptions or contracts, and it charges for the consults and treatment you use. It does not publish a price for women's hormone therapy on the pages we checked, so the cost depends on your consult and plan.
Sipra prices the medication into one number. The HRT cream (Bi-Est, estradiol and estriol) starts at $95/mo, estradiol tablets with progesterone at $190/mo, the brand Dotti patch with progesterone at $390/mo, progesterone alone at $85/mo, and vaginal estradiol at $99/mo. Membership is included in each price.
Defy's menopause pages post no women's price. Ask for the full cost, consults and medication, before you book.
Where each one falls short
Without a price on its menopause pages, Defy is hard to compare before you pay for a consult. It does not take insurance of any kind, though it offers a superbill.
Sipra's HRT cream is compounded. Compounded medications are not FDA-approved and are not the same as, or equivalent to, any branded product. Sipra does not offer injections, suppositories, or pellets, and it does not bill insurance. Sipra backs longer plans with the Sipra Promise, which refunds medication not yet sent to the pharmacy on 6 and 12 month plans if you stop partway through.
Defy Medical pros and cons
What is good
- No subscriptions or contracts, per its menopause page.
- One hour consults.
- Offers a superbill for out of network insurance claims.
What to weigh
- No price for women's hormone therapy on the pages we checked.
- No insurance billing of any kind.
- The filling pharmacies are not named.
sipra vs Defy Medical, side by side
| Defy Medical | |
|---|---|---|
| Billing model | One price per product, medication included | Pay per consult and treatment, no subscription |
| Estradiol forms | Bi-Est cream, tablets, or the brand Dotti patch | Injectable, topical, capsule, suppository, pellet |
| Progesterone | From $85/mo alone, or paired with estradiol | Part of its hormone plans |
| Vaginal estrogen | Vaginal estradiol from $99/mo | Not listed separately |
| Where you get it | Shipped to your door | Ordered through its patient portal |
| Labs | Quarterly protocol labs at $65/mo, optional | Verify on their site |
| Satisfaction policy | Sipra Promise refunds medication not yet sent to the pharmacy if you stop a 6 or 12 month plan | Verify their current policy |
| Trust check | LegitScript certified (50053943) | Verify their current standing |
As of 2026-10-30. Sipra's HRT cream is compounded and is not FDA-approved. It is not the same as, or equivalent to, any branded medication. A clinician decides what is appropriate for you. Individual results vary.
Who should choose which
Choose Defy Medical if
- You want long consults and a wide range of forms.
- You want no subscription at all.
- You plan to claim out of network with a superbill.
Choose sipra if
- You want to see the full price before you start.
- You want one price that already includes the medication.
- You want medication shipped to your door.
Frequently asked questions
Explore your hormone therapy options
- Online evaluation by a licensed clinician
- Treatment based on your health and goals
- Clear pricing before you commit
Free tools to help you decide
Was this helpful?